1H-Indazole-3-carboxylic acid, 1-methyl- → HCID 15224945, compound

HRID 976446Notes

Reaction equation

HRID 976446 reaction equation
[NH2:1][CH2:2][C:3]12[CH2:10][CH2:9][CH2:8][N:7]1[CH2:6][CH2:5][CH2:4]2.[CH3:11][N:12]1[C:20]2[C:15](=[CH:16][CH:17]=[CH:18][CH:19]=2)[C:14]([C:21](O)=[O:22])=[N:13]1>>[CH3:11][N:12]1[C:20]2[C:15](=[CH:16][CH:17]=[CH:18][CH:19]=2)[C:14]([C:21]([NH:1][CH2:2][C:3]23[CH2:10][CH2:9][CH2:8][N:7]2[CH2:6][CH2:5][CH2:4]3)=[O:22])=[N:13]1

Participants

3

Reactant 2

HCID 6891051H-Indazole-3-carboxylic acid, 1-methyl-HCID 10654304(Hexahydro-1H-pyrrolizin-7A-YL)methanamine

Product 1

HCID 15224945HCID 15224945, compound

Procedure

Following the procedure of example 1, 7a-Aminomethylhexahydro-1H-pyrrolizine is reacted with N-methylindazole-3-carboxylic acid [J. Medicinal Chemistry (1987) 30: 1535] to afford the title compound.

Sources & evidence

ORD record
ord-e41b4a3773e740a6a84fb22122779b5d
Source dataset
uspto-grants-1997_03
Patent number
US05612366

Reaction notes

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