Sodium Hydroxide → HCID 19967277, compound

HRID 976462Notes

Reaction equation

HRID 976462 reaction equation
C([O:4][C:5]1[CH:6]=[C:7]([CH2:17][O:18][NH:19][C:20](=[O:22])[CH3:21])[C:8]2[C:13]([CH:14]=1)=[CH:12][CH:11]=[C:10]([O:15][CH3:16])[CH:9]=2)(=O)C.[OH-].[Na+]>CO>[OH:4][C:5]1[CH:6]=[C:7]([CH2:17][O:18][NH:19][C:20](=[O:22])[CH3:21])[C:8]2[C:13]([CH:14]=1)=[CH:12][CH:11]=[C:10]([O:15][CH3:16])[CH:9]=2

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 19967262HCID 19967262, compound

Product 1

HCID 19967277HCID 19967277, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

The residue obtained in Example 56 is dissolved in 200 cm3 of methanol and treated with 250 cm3 of 0.05N NaOH for 1 hour at room temperature. The methanol is evaporated and the mixture is adjusted to pH 12 with 1N NaOH, extracted with CH2Cl2, dried over MgSO4, filtered and concentrated. After chromatography on silica, the title compound is obtained.

Workup

  1. customThe methanol is evaporated
  2. extractionextracted with CH2Cl2
  3. dry with materialdried over MgSO4
  4. filtrationfiltered
  5. concentrationconcentrated

Sources & evidence

ORD record
ord-208eed77b0f64c2ab9174dd62df2d53e
Source dataset
uspto-grants-1997_03
Patent number
US05612368

Reaction notes

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