98061-65-5 → HCID 86750587, compound

HRID 976478Notes

Reaction equation

HRID 976478 reaction equation
Br[CH2:2]/[C:3](=[CH:7]\[C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1)/[C:4]([OH:6])=[O:5].[C:14]([OH:20])(=[S:19])[C:15]([CH3:18])([CH3:17])[CH3:16]>>[C:14]([S:19][CH2:2]/[C:3](=[CH:7]\[C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1)/[C:4]([OH:6])=[O:5])(=[O:20])[C:15]([CH3:18])([CH3:17])[CH3:16]

Participants

3

Reactant 2

HCID 602327098061-65-5HCID 178447641HCID 178447641, compound

Product 1

HCID 86750587HCID 86750587, compoundYield 93%

Procedure

The (Z)-2-bromomethyl-3-phenylpropenoic acid described in Example 1 (step A) is reacted with thiopivaloic acid according to the experimental procedure described in Example 1 (step B). Yield: 93% 1H NMR (CDCl3): 9.10 (broad s, 1H); 7.90 (s, 1H); 7.35 (s, 5H); 4.00 (s, 2H); 1.20 (s, 9H)

Sources & evidence

ORD record
ord-22955ca6b16b46e3a594166941e075d5
Source dataset
uspto-grants-1997_03
Patent number
US05612371

Reaction notes

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