Benzyl 3-aminopropanoate → HCID 19037116, compound

Participants

Reaction Steps

The (Z)-2-acetylthiomethyl-3-(4-propoxyphenyl)propenoic acid obtained in step C is coupled with benzyl β-alaninate according to the experimental procedure described in Example 1 (step D). Yield=66% (purification by flash chromatography, eluent: ether/petroleum ether 65/35)-oil IR: 3280, 1740, 1690, 1645, 1620 cm-1 1H NMR (CDCl3 /TMS): 7.50 (s, 1H); 7.35 to 7.15 (m, 7H); 6.95 to 6.75 (m, 3H); 5.15 (s, 2H); 4.00 to 3.50 (m, 6H); 2.65 (t, 2H, J=6 Hz); 2.30 (s, 3H); 1.80 (m, 2H, J app.=8 Hz); 1.00 (t, 3H, J=8 Hz). Microanalysis: C25H29O5NS Calc. % C=65.91 H=6.42 N=3.07 Found. % C=65.80 H=6.38 N=2.91

Provenance & Evidence