Benzyl 3-aminopropanoate → HCID 19037105, compound

Participants

Reaction Steps

The above (Z) acid is coupled with benzyl β-alaninate according to the experimental procedure described in Example 1 (step D). Yield: 57% (after flash chromatography, eluent ether/petroleum ether 60/40). m.p. 81° C. IR (nujol): 3290, 1740, 1695, 1640, 1620 cm-1 1H NMR (CDCl3 /TMS): 8.20 (s, 1H); 8.00 to 7.70 (m, 3H); 7.65 to 7.00 (m, 10H); 5.20 (s, 2H); 3.90 (s, 2H); 3.65 to 3.45 (m, 2H); 2.65 (t, 2H, J=6 Hz); 2.35 (s, 3H). Microanalysis: C26H25O4NS Calc. % C=69.78 H=5.63 N=3.13 Found. % C=69.86 H=5.68 N=3.17

Provenance & Evidence