Benzyl 3-aminopropanoate → HCID 15287118, compound

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Reaction Steps

The (Z)-2-acetylthiomethyl-3-phenylpropenoic acid described in Example 1 (step B) is coupled with benzyl β-alaninate according to the experimental procedure described in Example 1 (step D). Yield: 78% (after recrystallization in ether) m.p. 80° C. IR: 3380, 1720, 1670, 1630, 1600 cm-1 1H NMR (CDCl3): 7.60 (s, 1H); 7.45 to 7.15 (m, 10H); 6.90 (broad t, 1H; 5.15 (s, 2H); 3.95 (s, 2H); 3.65 (q. app., J:6.1 Hz); 2.65 (t, 2H, J=6.1 Hz); 2.35 (s, 3H). Microanalysis: C22H23NO4S Calc. % C=60.48 H=5.83 N=3.52 Found. % C=66.29 H=5.78 N=3.51

Provenance & Evidence