2-Mercaptoethanol → 3-[(2-Hydroxyethyl)thio]-1,2-propanediol

Temperature

50 °C

In a reaction vessel equipped with a stirrer, a cooling tube, a nitrogen introducing tube and a thermometer, 78.1 parts of 2-mercaptoethanol was charged, and 2-mercaptoethanol was diluted with 159.6 parts of MIBK. Then, 0.41 part of dimethylbenzylamine was added and, after heating to 50° C., 81.5 parts of glycidol was added dropwise with stirring over 3 hours in a dry nitrogen atmosphere. The reaction vessel was cooled and maintained at 50° C. 2 Hours after dropping, it was confirmed that an absorption of --SH (2540 cm-1) and an absorption of a glycidyl group (910 cm-1) are disappeared by the measurement of infrared spectra. Further, the reaction product had no mercapto-like odor. Thereafter, MIBK was removed under reduced pressure to give 1-(2-hydroxyethylthio)-2,3-propanediol as a viscous liquid. Yield was 90% of the charge weight.

1. customIn a reaction vessel equipped with a stirrer, a cooling tube, a nitrogen introducing tube
2. temperatureThe reaction vessel was cooled
3. temperaturemaintained at 50° C
4. customit was confirmed that an absorption of --SH (2540 cm-1)
5. customan absorption of a glycidyl group (910 cm-1)
6. customThereafter, MIBK was removed under reduced pressure

ORD record

ord-85c83228136148a383cf6cfee9edcbb3

Source dataset

uspto-grants-1997_03

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US05612395