Ethanol hydrochloride → 1-(Benzo[b]thiophen-5-yl)-2-[(piperazin-2-yl)methoxy]ethanol dihydrochloride

HRID 976549Notes

Reaction equation

HRID 976549 reaction equation
[S:1]1[CH:5]=[CH:4][C:3]2[CH:6]=[C:7]([CH:10]([OH:24])[CH2:11][O:12][CH2:13][CH:14]3[CH2:19][N:18](C=O)[CH2:17][CH2:16][N:15]3C=O)[CH:8]=[CH:9][C:2]1=2.[ClH:25].C(O)C>CO>[ClH:25].[ClH:25].[S:1]1[CH:5]=[CH:4][C:3]2[CH:6]=[C:7]([CH:10]([OH:24])[CH2:11][O:12][CH2:13][CH:14]3[CH2:19][NH:18][CH2:17][CH2:16][NH:15]3)[CH:8]=[CH:9][C:2]1=2

Participants

4

Reactant 2

HCID 21887872Ethanol hydrochlorideHCID 53826975(Benzo[b]thiophen-5-yl)-2-[(1,4-diformylpiperazin-2-yl)methoxy]ethanol

Product 1

HCID 675982851-(Benzo[b]thiophen-5-yl)-2-[(piperazin-2-yl)methoxy]ethanol dihydrochloride

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

In 1.5 ml of methanol was dissolved 270 mg of 1-(benzo[b]thiophen-5-yl)-2-[(1,4-diformylpiperazin-2-yl)methoxy]ethanol. To the solution was added 1.5 ml of a 5N dry hydrogen chloride-ethanol solution. The resulting mixture was allowed to stand at room temperature overnight. The resulting crystals were collected by filtration, washed with ethanol, and dried to obtain 150 mg of 1-(benzo[b]thiophen-5-yl)-2-[(piperazin-2-yl)methoxy]ethanol dihydrochloride (compound No. 355).

Workup

  1. filtrationThe resulting crystals were collected by filtration
  2. washwashed with ethanol
  3. customdried

Sources & evidence

ORD record
ord-f371d22848814e059434d35938ff945b
Source dataset
uspto-grants-1997_03
Patent number
US05612381

Reaction notes

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