Water → HCID 131719929, compound

Participants

Reaction Conditions

Reaction Steps

5-(2-Cyanophenyl)-1-[1-(4-trifluoromethylphenyl)-1pentyl]indole (1.9 moles, 800 mg) was dissolved in 2.0 g of tributyltinazide and heated at 95° C. for 24 hours. The solution was cooled. Acetonitrile, water, and acetic acid (50 ml of 8:1:1) were added. The acetonitrile solution was washed with hexane, concentrated, diluted with ethyl acetate, washed with water, dried over sodium sulfate and concentrated. The product was chromatographed on silica gel eluted with ethyl acetate to yield 120 mg of 5-[2-tetrazol-5-yl)phenyl]-1-[1-(4- trifluoromethylphenyl)-1-pentyl]indole.

Provenance & Evidence