Pyrrolidine → HCID 178509652, compound

Participants

Reaction Steps

2-Chloromethyl-5-(2-cyanophenyl)-1H-benzimidazole (2.28 mmoles, 0.54 g - see Example 35) and pyrrolidine (5.26 mmole, 0.375 g.) were dissolved in THF and stirred room temperature. The solvents were removed in vacuo. The residue was dissolved in ethyl acetate, washed with water, and concentrated to yield 0.583 g of 5-(2-Cyanophenyl)-2-(1-pyrrolidinomethyl)-1H-benzimidazole.

Provenance & Evidence