1-(1-Ethylpropyl)-1-hydroxy-3-phenylurea → 1-Hydroxy-1-(1-ethylpropyl)-3-(4'-octyloxybiphenyl-4-yl)urea

HRID 976612Notes

Reaction equation

HRID 976612 reaction equation
[OH:1][N:2]([CH3:14])[C:3]([NH:5][C:6]1[CH:11]=[CH:10][C:9](SC)=[CH:8][CH:7]=1)=[O:4].ON(C(C)C)C(N[C:20]1[CH:25]=[CH:24][C:23](SC)=[CH:22][CH:21]=1)=O.C(C(N(O)C(N[C:40]1[CH:45]=[CH:44][CH:43]=[CH:42][CH:41]=1)=O)CC)C.ON(C)C(NC1C=C[C:55]([O:58]C2C=CC=CC=2)=[CH:54]C=1)=O.ON(C(CC)CC)C(N[C:71]1C=CC(OC2C=CC=CC=2)=C[CH:72]=1)=O.ON(C(CC)CC)C(N[C:94]1C=CC=C[C:95]=1OC1C=CC=CC=1)=O.ON(C(C)C)C(NC1C=CC(CCCC)=CC=1)=O.ON(C(C)CC)C(NC1C=CC=CC=1)=O.ON(C(CC)CC)C(NC1C=CC=C(OC2C=CC=CC=2)C=1)=O>>[OH:1][N:2]([CH:14]([CH2:94][CH3:95])[CH2:71][CH3:72])[C:3]([NH:5][C:6]1[CH:11]=[CH:10][C:9]([C:20]2[CH:21]=[CH:22][C:23]([O:58][CH2:55][CH2:54][CH2:41][CH2:42][CH2:43][CH2:44][CH2:45][CH3:40])=[CH:24][CH:25]=2)=[CH:8][CH:7]=1)=[O:4]

Participants

10

Reactant 9

HCID 113790611-(1-Ethylpropyl)-1-hydroxy-3-phenylureaHCID 115722631-Hydroxy-1-(1-methylethyl)-3-[4-(methylthio)phenyl]ureaHCID 115937101-Hydroxy-1-methyl-3-[4-(methylthio)phenyl]ureaHCID 116525761-Hydroxy-1-(1-ethylpropyl)-3-(3-phenoxyphenyl)ureaHCID 127707111-Hydroxy-1-(1-methylpropyl)-3-phenylureaHCID 199673731-Hydroxy-1-(1-ethylpropyl)-3-(2-phenoxyphenyl)ureaHCID 199673811-Hydroxy-1-(1-ethylpropyl)-3-(4-phenoxyphenyl)ureaHCID 199674301-Hydroxy-1-(1-methylethyl)-3-(4-butylphenyl)ureaHCID 199674431-Hydroxy-1-methyl-3-(4-phenoxyphenyl)urea

Product 1

HCID 199673651-Hydroxy-1-(1-ethylpropyl)-3-(4'-octyloxybiphenyl-4-yl)urea

Procedure

1-Hydroxy-1-methyl-3-[4-(methylthio)phenyl]urea, 1-hydroxy-1-(1-methylethyl)-3-[4-(methylthio)phenyl]urea, 1-(1-ethylpropyl)-1-hydroxy-3-(4-methylthio)phenyurea, 1-(1-ethylpropyl)-1-hydroxy-3-phenylurea, 1-hydroxy-1-methyl-3-(4-phenoxyphenyl)urea, 1-hydroxy-1-(1-ethylpropyl)-3-(4-phenoxyphenyl)urea, 1-hydroxy-1-(1-ethylpropyl)-3-(2-phenoxyphenyl)urea, 1-hydroxy-1-(1-methylethyl)-3-(4-butylphenyl)urea, 1-hydroxy-1-(1-methylpropyl)-3-phenylurea, and 1-hydroxy-1-(1-ethylpropyl)-3-(3-phenoxyphenyl)urea are most preferred.

Sources & evidence

ORD record
ord-4107aa4dac4e4ca39484fb768949fa09
Source dataset
uspto-grants-1997_03
Patent number
US05612377

Reaction notes

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