反应详情

Phenyl isocyanate (3.2 g, 27 mmol) was added via pipette to a solution of N-benyloxy-N-(2-methylpropyl)amine (4.8 g, 27 mmol) in methylene chloride (30 mL). The reaction mixture was allowed to stir at ambient temperature for 3 days. The solvent was removed under vacuum. The residue was purified by column chromatography (silica gel; 1:9 ethyl acetate:hexanes) to provide 6.2 g of 1-benzyloxy-1-(2-methylpropyl)-3-phenylurea as a white crystalline solid, m.p. 85°-87° C. Analysis: Calculated for C18H22N2 : %C, 72.46; %H, 7.43; %N, 9.39; Found: %C, 72.53; %H, 7.51; %N, 9.44.

1. customThe solvent was removed under vacuum
2. customThe residue was purified by column chromatography (silica gel; 1:9 ethyl acetate:hexanes)