3,5-Bis(trifluoromethyl)phenyl isocyanate → 1-Hydroxy-1-(1-ethylpropyl)-3-(3,5-bis(trifluoromethyl)phenyl)urea

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Reaction Steps

Using the method of Compound 72, 3,5-bis(trifluoromethyl)phenylisocyanate (1.3 g, 5.1 mmole) was reacted with N-(1-ethylpropyl)hydroxylamine (0.58 g, 5.6 mmole) to provide 160 mg of the desired product as a white crystalline solid, m.p. 115°-116° C. Analysis: Calculated for: C14H16F6N2O2 : %C, 46.93; %H, 4.5; %N, 7.82; Found: %C, 46.8; %H, 4.37; %N, 7.89.

Provenance & Evidence