(1,1'-Biphenyl)-4-carboxylic acid → HCID 19967379, compound

HRID 976656Notes

Reaction equation

HRID 976656 reaction equation
[C:1]1([C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=2)[CH:6]=[CH:5][C:4](C(O)=O)=[CH:3][CH:2]=1.[N-:16]=[C:17]=[O:18].[CH2:19]([CH:21]([NH:24][OH:25])[CH2:22][CH3:23])[CH3:20]>>[OH:25][N:24]([CH:21]([CH2:22][CH3:23])[CH2:19][CH3:20])[C:17]([NH:16][C:4]1[CH:3]=[CH:2][C:1]([C:10]2[CH:11]=[CH:12][CH:13]=[CH:14][CH:15]=2)=[CH:6][CH:5]=1)=[O:18]

Participants

4

Reactant 3

HCID 66724(1,1'-Biphenyl)-4-carboxylic acidHCID 105034IsocyanateHCID 19073513N-(pentan-3-yl)hydroxylamine

Product 1

HCID 19967379HCID 19967379, compound

Procedure

Using the general method of Compound 76, 4-biphenylcarboxylic acid (1.3 g, 6.5 mmole) was converted to the isocyanate then reacted with N-(1-ethylpropyl)hydroxylamine (1.0 g, 10 mmole) to provide 0.54 g of the desired product as a white crystalline solid, m.p. 183°-184° C. Analysis: Calculated for C18H22N2O2 : %C, 72.46; %H, 7.43; %N, 9.39; Found: %C, 72.38; %H, 7.15; %N, 9.26.

Sources & evidence

ORD record
ord-f131eaad6e7346ebbcfb9058f26ba36b
Source dataset
uspto-grants-1997_03
Patent number
US05612377

Reaction notes

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