HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Dithionite → 2,5,6-Triamino-4-Benzyloxypyrimidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Dithionite | HCID 24489 | — |
| Reactant | 2,4-Pyrimidinediamine, 5-nitroso-6-(phenylmethoxy)- | HCID 181029 | — |
| Solvent | Water | HCID 962 | — |
| Product | 2,5,6-Triamino-4-Benzyloxypyrimidine | HCID 9816044 | — |
Reaction Steps
Sodium dithionite is added in portions to a suspension of 17 g 5-nitroso-2,4-diamino-6-benzyloxy-primidine (8) in 300 mL H2O at 50° C. until the red nitroso compound is fully reduced. The free base is separated out by adding aqueous ammonia. The crude product is cooled, suctioned off and crystallized from water, to which activated charcoal and a trace of sodium dithionite is added yielding 9.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05612468 |
| Source dataset | uspto-grants-1997_03 |
| ORD ID | ord-5eed9d62d29b4ff89a5319ce5cc955cb |
| Source note | uspto-grants-1997_03 |