Sodium Methoxide → HCID 54545679, compound

HRID 976943Notes

Reaction equation

HRID 976943 reaction equation
[NH2:1][C:2]1[C:11]2[C:6](=[N:7][CH:8]=[CH:9][N:10]=2)[N:5]([C@@H:12]2[O:26][C@H:25]([CH2:27][O:28]C(C3C(C)=CC=CC=3)=O)[C@@H:14]([O:15]C(C3C(C)=CC=CC=3)=O)[CH2:13]2)[C:4](=[O:38])[N:3]=1.C[O-].[Na+]>CC(O)=O>[NH2:1][C:2]1[C:11]2[C:6](=[N:7][CH:8]=[CH:9][N:10]=2)[N:5]([C@@H:12]2[O:26][C@H:25]([CH2:27][OH:28])[C@@H:14]([OH:15])[CH2:13]2)[C:4](=[O:38])[N:3]=1

Participants

4

Reactant 2

HCID 10942334Sodium MethoxideHCID 67674470HCID 67674470, compound

Product 1

HCID 54545679HCID 54545679, compound

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

To 0.51 g (1 mmole) of 4-amino-1-(2-deoxy-3,5-di-O-toluoyl-β-D-ribofuranosyl)-pteridine-2-one (31) is added 50 mL of 0.0005N sodium methoxide. The mixture is stirred at room temperature for 24 h. The mixture is then neutralized with AcOH, evaporated to dryness, and twice coevaporated with H2O. The residue is then recrystallized from 50 mL of ethanol to give 32.

Workup

  1. customevaporated to dryness
  2. customThe residue is then recrystallized from 50 mL of ethanol

Sources & evidence

ORD record
ord-9c8864a438da4699b38731c2e89e9c20
Source dataset
uspto-grants-1997_03
Patent number
US05612468

Reaction notes

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