Trifluoroacetic acid → HCID 131719930, compound

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Reaction Steps

A mixture of t-butyl 4-[3-(1-t-butoxycarbonylpiperidin-4-ylcarbonyl)carbazoyl]-2-(t-butoxycarbonylmethoxy)phenoxyacetate (360 mg) and TFA (4 ml) in dichloromethane (8 ml) was stirred at ambient temperature for 5 hours. The solvent was removed by evaporation and the residue was triturated with ether to give the title compound as a solid; NMR Spectrum (d6 -DMSO) 1.68-2.02 (m, 4H), 2.55-2.68 (m, 1H), 2.85-3.05 (dt, 2H), 3.2-3.4 (br d, 2H), 4.74 (s, 2H), 4.78 (s, 2H), 6.97 (d, 1H), 7.4 (s, 1H), 7.47 (dd, 1H), 8.5 (br s, 2H), 9.9 (s, 1H), 10.2 (s, 1H); Mass Spectrum (+ve FAB, MeOH/NBA): 396 (M+H)+.

Provenance & Evidence