反应详情

1 g of N-(1-adamantyl)-4-acetoxy-3-nitrocinnamamide (prepared as described in Example 1) was dissolved in 30 ml of methanol; 30 ml of a 4N aqueous solution of sodium hydroxide were then added, and the resulting mixture was stirred for 3 hours at room temperature. At the end of this time, the methanol was removed by distillation under reduced pressure. Addition of 3N aqueous hydrochloric acid to the residue afforded crystals of the title compound, melting at 162°-163° C.

1. customAt the end of this time, the methanol was removed by distillation under reduced pressure
2. additionAddition of 3N aqueous hydrochloric acid to the residue