Sodium Hydroxide → HCID 53898632, compound

HRID 977083Notes

Reaction equation

HRID 977083 reaction equation
[C:1]12([NH:11][C:12](=[O:28])[CH:13]=[CH:14][C:15]3[CH:20]=[CH:19][C:18]([O:21]C(=O)C)=[C:17]([N+:25]([O-:27])=[O:26])[CH:16]=3)[CH2:10][CH:5]3[CH2:6][CH:7]([CH2:9][CH:3]([CH2:4]3)[CH2:2]1)[CH2:8]2.[OH-].[Na+]>CO>[C:1]12([NH:11][C:12](=[O:28])[CH:13]=[CH:14][C:15]3[CH:20]=[CH:19][C:18]([OH:21])=[C:17]([N+:25]([O-:27])=[O:26])[CH:16]=3)[CH2:10][CH:5]3[CH2:4][CH:3]([CH2:9][CH:7]([CH2:6]3)[CH2:8]1)[CH2:2]2

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 53874822N-(1-Adamantyl)-4-acetoxy-3-nitrocinnamamide

Product 1

HCID 53898632HCID 53898632, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

1 g of N-(1-adamantyl)-4-acetoxy-3-nitrocinnamamide (prepared as described in Example 1) was dissolved in 30 ml of methanol; 30 ml of a 4N aqueous solution of sodium hydroxide were then added, and the resulting mixture was stirred for 3 hours at room temperature. At the end of this time, the methanol was removed by distillation under reduced pressure. Addition of 3N aqueous hydrochloric acid to the residue afforded crystals of the title compound, melting at 162°-163° C.

Workup

  1. customAt the end of this time, the methanol was removed by distillation under reduced pressure
  2. additionAddition of 3N aqueous hydrochloric acid to the residue

Sources & evidence

ORD record
ord-bf31d1f23ce549bc81995fa05f1eb89a
Source dataset
uspto-grants-1997_03
Patent number
US05614521

Reaction notes

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