4-Carbamothioylbenzoic acid → 2-(4-Carboxyphenyl)-4-methyl-5-thiazolecarboxylic acid

HRID 977093Notes

Reaction equation

HRID 977093 reaction equation
C(C1C=CC(C(O)=O)=CC=1)(=S)N.[C:13]([C:16]1[CH:21]=[CH:20][C:19]([C:22]2[S:23][C:24]([C:28]([O:30]CC)=[O:29])=[C:25]([CH3:27])[N:26]=2)=[CH:18][CH:17]=1)([OH:15])=[O:14]>>[C:13]([C:16]1[CH:17]=[CH:18][C:19]([C:22]2[S:23][C:24]([C:28]([OH:30])=[O:29])=[C:25]([CH3:27])[N:26]=2)=[CH:20][CH:21]=1)([OH:15])=[O:14]

Participants

3

Reactant 2

HCID 167725014-Carbamothioylbenzoic acidHCID 19965068Ethyl 2-(4-carboxyphenyl)-4-methyl-5-thiazolecarboxylate

Product 1

HCID 199651712-(4-Carboxyphenyl)-4-methyl-5-thiazolecarboxylic acid

Procedure

2-(4-Carboxyphenyl)-4-methyl-5-thiazolecarboxylic acid was prepared from 4-thiocarbamoylbenzoic acid through an ethyl 2-(4-carboxyphenyl)-4-methyl-5-thiazolecarboxylate in the same manner as that of Example 13 (yield: 49%).

Sources & evidence

ORD record
ord-4015d589a07d4a10a336a66c96ae5271
Source dataset
uspto-grants-1997_03
Patent number
US05614520

Reaction notes

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