HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methyl iodide → HCID 19965084, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methyl iodide | HCID 6328 | — |
| Reactant | Sodium hydride | HCID 24758 | — |
| Reactant | HCID 19965109 | HCID 19965109 | — |
| Product | HCID 19965084 | HCID 19965084 | 72% |
Reaction Steps
100 mg of Ethyl 2-(4-(4-chlorophenylcarbamoyl)-phenyl)-4-methyl-5-thiazolecarboxylate produced in Example 16 was methylated with sodium hydride and methyl iodide, and hydrolyzed by a conventional process to give 69 mg of 2-(4-(N-(4-chlorophenyl)-N-methylcarbamoyl)phenyl)-4-methyl-5-thiazolecarboxylic acid (yield: 72%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05614520 |
| Source dataset | uspto-grants-1997_03 |
| ORD ID | ord-04ed7d181aac4d79bfe2187d5a2f368b |
| Source note | uspto-grants-1997_03 |