Acetyl chloride → HCID 54459541, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 0.30 g of 1-[(tetrahydro-3-furanyl) methyl]-2-(nitroimino)hexahydropyrimidine, 0.07 g of sodium hydride (60%) and 10 ml of acetonitrile was stirred at 50° C. for 30 minutes. After this mixture was cooled on ice, 0.11 g of acetyl chloride was dropwise added thereto over 10 minutes, and the mixture was then stirred at room temperature for 2 hours. After the completion of reaction, insolubles were removed by filtration, and concentration was then carried out under a reduced pressure. The resultant oily substance was purified by silica gel column chromatography (2:1 ethyl acetate/acetone) to obtain 0.06 g of 1-(methylcarbonyl)-2-(nitroimino)-3-[(tetrahydro-3-furanyl)methyl]hexahydropyrimidine.

Provenance & Evidence