Butyryl chloride → HCID 53803196, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 0.30 g of 1-[(tetrahydro-3-furanyl)methyl]-2-(nitroimino)imidazolidine, 0.084 g of sodium hydride (60%) and 10 ml of acetonitrile was stirred at 50° C. for 30 minutes. After this mixture was cooled on ice, 0.22 g of n-butanoyl chloride was added dropwise thereto over 30 minutes, and the solution was then stirred at room temperature for 2 hours. After the completion of reaction, insolubles were removed by filtration, and the filtrate was then concentrated under a reduced pressure. The resultant residue was purified by silica gel column chromatography (2:1 ethyl acetate/acetone) to obtain 0.27 g of 1-(propylcarbonyl)-2-(nitroimino)-3-[(tetrahydro-3-furanyl) methyl]imidazolidine.

Provenance & Evidence