Sodium hydride → HCID 54041915, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 3.0 g of 1-[(tetrahydro-3-furanyl)methyl]-2-(nitroimino)hexahydropyrimidine, 0.70 g of sodium hydride (60%) and 100 ml of acetonitrile was stirred at 50° C. for 30 minutes. After this mixture was cooled on ice, 1.60 g of propionyl chloride was added dropwise thereto over 30 minutes, and the solution was then stirred at room temperature for 2 hours. After the completion of reaction, insolubles were removed by filtration, and the filtrate was then concentrated under a reduced pressure. The resultant residue was purified by silica gel column chromatography (2:1 ethyl acetate/acetone) to obtain 0.80 g of 1-propionyl-2-(nitroimino)-3-[(tetrahydro-3-furanyl)methyl]hexahydropyrimidine.

Provenance & Evidence