Hydrochloric Acid → HCID 136133141, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 2.0 g of 1-(1-propenyl)-2-nitroimino-3-[(tetrahydro-3-furanyl)methyl]imidazolidine, 20 ml of 2N hydrochloric acid and 20 ml of ethanol was stirred at 60° C. for 3 hours. After the completion of reaction, the reaction mixture was neutralized with an aqueous solution of saturated sodium bicarbonate, followed by extraction with methylene chloride three times. Next, the extract was dried over sodium sulfate, anhydrous and then concentrated under a reduced pressure. The resultant oily substance was purified by silica gel column chromatography (ethyl acetate) to obtain 1.02 g of 1-[(tetrahydro-3furanyl)methyl]-2-(nitroimino)imidazolidine as a pale yellow oil.

Provenance & Evidence