Ethanol → HCID 136381083, compound

Participants

Reaction Steps

Afterward, a mixture of 1.00 g Of N-[(tetrahydro-2-furanyl) methyl]ethylenediamine, 0.77/g of S-methyl-N-nitroisothiourea, 0.1 g of N,N-dimethylaminopyridine (DMAP) and 10 ml of ethanol was refluxed. After the completion of reaction, ethyl acetate was added, and insolubles were then removed by filtration. The filtrate was concentrated under a reduced pressure, and the precipitated crystals were then removed by filtration. Next, the filtrate was concentrated under a reduced pressure, and the resultant residue was purified by silica gel column chromatography (1:2 acetone/ethyl acetate) to obtain 0.25 g of 1-[(tetrahydro-2-furanyl) methyl]-2(nitroimino)imidazolidine as a pale yellow oil.

Provenance & Evidence