4-Methylmorpholine → HCID 15295423, compound

Participants

Reaction Steps

6.6 g of 4-(7-cyanoimidazo[1,2-a]pyridin-2-yl)benzoic acid [obtainable as in Example 5]in 100 ml of dichloromethane and 25 ml of DMF are stirred with 4.5 g of β-alanine tert-butyl ester in the presence of 5.25 g of N-(3-dimethylaminopropyl)-N'-ethylcarbodiimide and 6 ml of N-methylmorpholine at room temperature for 20 h. This is followed by extraction 3-4 times with 30 ml of water each time, evaporation and the customary working-up. Tert-butyl 3-[4-(7-cyanoimidazo[1,2-a]pyridin-2-yl)benzamido]propionate is obtained, m.p. 212° (decomposition).

Provenance & Evidence