HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Methylmorpholine → HCID 19965297, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Methylmorpholine | HCID 7972 | — |
| Reactant | 1-Ethyl-3-(3'-dimethylaminopropyl)carbodiimide | HCID 15908 | — |
| Reactant | Ethyl 3-aminopropanoate | HCID 419889 | — |
| Reactant | HCID 19965292 | HCID 19965292 | — |
| Reactant | HCID 178418300 | HCID 178418300 | — |
| Solvent | Water | HCID 962 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 19965297 | HCID 19965297 | — |
Reaction Steps
4.0 g Of 4-(8-cyanoimidazo[1,2-a]pyridin-2-yl)benzoic acid and 2.14 g of ethyl 3-aminopropionate in 40 ml of DMF are stirred in the presence of 2.28 g of hydroxybenzotriazole, 3.0 g of N-methylmorpholine and 2.9 g of N-(3-dimethylaminopropyl)-N'-ethylcarbodiimide at room temperature for 4 h. After addition of 400 ml of water, the precipitate is filtered off with suction and washed successively with dilute bicarbonate solution and water. Methyl 3-[4-(8-cyanoimidazo[1,2-a]pyridin-2-yl)benzamido]propionate, m.p 201-204° is obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05614531 |
| Source dataset | uspto-grants-1997_03 |
| ORD ID | ord-c40ca525c90242819792745a4ca17b1e |
| Source note | uspto-grants-1997_03 |