HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Methoxyphenylacetic Acid → 7-chloro-3-(4-methoxyphenyl)-1H-quinolin-2-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Methoxyphenylacetic Acid | HCID 7690 | — |
| Reactant | (2-Amino-4-chlorophenyl)methanol | HCID 4134900 | — |
| Product | 7-chloro-3-(4-methoxyphenyl)-1H-quinolin-2-one | HCID 12278041 | — |
Reaction Steps
2-Amino-4-chlorobenzyl alcohol (4 g, 25.3 mol) and 4-methoxyphenyl acetic acid (14.0 g, 76.4 mmol) were reacted in a similar manner to that described in Example 19 to give 7-chloro-3-(4-methoxyphenyl)-2(1H)-quinolone; mp 256°-257° C. (ethyl acetate).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05614532 |
| Source dataset | uspto-grants-1997_03 |
| ORD ID | ord-f5dd0505cc9546ce813bbffe2d636fcd |
| Source note | uspto-grants-1997_03 |