HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 977201Generated: October 25, 2026
Piperidine → 5-[(3,4-Dihydroxy-5-nitrophenyl)methylidene]-3-methyl-2-thioxothiazolidin-4-one
https://huagongshe.com/reaction/977201
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Piperidine | HCID 8082 | — |
| Reactant | 4-Thiazolidinone, 3-methyl-2-thioxo- | HCID 72900 | — |
| Reactant | 3,4-Dihydroxy-5-nitrobenzaldehyde | HCID 5748957 | — |
| Solvent | Acetic Acid | HCID 176 | — |
| Product | 5-[(3,4-Dihydroxy-5-nitrophenyl)methylidene]-3-methyl-2-thioxothiazolidin-4-one | HCID 53867513 | — |
Reaction Steps
A solution containing 0.74 g (0.005 mol) of 3-methyl-2-thioxothiazolidin-4-one, 0.92 g (0.005 mol) of 3,4-dihydroxy-5-nitrobenzaldehyde, 0.05 ml of piperidine in 10 ml of acetic acid was heated for 8 h at 100° C. The product was filtered and washed with 2-propanol. Yield 0.87 g (56%), mp 274°-276° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US05614541 |
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| Source dataset | uspto-grants-1997_03 |
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| ORD ID | ord-f3417c79332a491083a2dbbd928c35e9 |
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| Source note | uspto-grants-1997_03 |
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