Hydrochloric Acid → 1-[3-(4-Amidinophenyl)-2-oxo-5-oxazolidinylcarbonyl]piperidine-4-carboxylic acid, hydrochloride

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Reaction Steps

0.41 g of tert-butyl 1-[3-(4-amidinophenyl)-2-oxo-5-oxazolidinylcarbonyl}piperidin-4-yl-carboxylate is stirred in 40 ml of ethereal HCl solution at room temperature for 2 h. The precipitate formed is filtered off with suction and washed with 20 ml of ether. The product is then treated with 5 ml of acetonitrile at 60° for 10 min, the mixture is cooled to room temperature, and the product is filtered off with suction and washed with a little acetonitrile. 1-[3-(4-amidinophenyl)-2-oxo-5-oxazolidinylcarbonyl]piperidine-4-carboxylic acid, hydrochloride, m.p. 184° (decomposition), is obtained.

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