Trifluoroacetic acid → Trifluoroacetate

Participants

Reaction Steps

0.25 g of tert-butyl (2R)-2-[3-(4-amidinophenyl)-2-oxo-5-oxazolidinylcarbonylamino)-3phenylpropionate [obtainable according to Example 12]is stirred in 10 ml of trifluoroacetic acid at room temperature until hydrolysis is complete. The reaction mixture is subsequently concentrated and the residue is washed repeatedly with toluene. Treatment with ethyl acetate gives (2R)-2-[3-(4-amidinophenyl)-2-oxo-5-oxazolidinylcarbonylamino]-3-phenylpropionic acid, trifluoroacetate, FAB (M+1): 397.

Provenance & Evidence