HCID 19965556, compound → Benzyl 3-{1-[3-(4-tert-butoxycarbonylaminomethylphenyl)-2-oxo-5-oxazolidinylcarbonyl]-4-piperazinyl}propionate

HRID 977217Notes

Reaction equation

HRID 977217 reaction equation
[N:1]1([CH2:7][CH2:8][C:9]([O:11][CH2:12][C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)=[O:10])[CH2:6][CH2:5][NH:4][CH2:3][CH2:2]1.[C:19]([O:23][C:24]([NH:26][CH2:27][C:28]1[CH:33]=[CH:32][C:31]([N:34]2[CH2:38][CH:37]([C:39](O)=[O:40])[O:36][C:35]2=[O:42])=[CH:30][CH:29]=1)=[O:25])([CH3:22])([CH3:21])[CH3:20]>>[C:19]([O:23][C:24]([NH:26][CH2:27][C:28]1[CH:33]=[CH:32][C:31]([N:34]2[CH2:38][CH:37]([C:39]([N:4]3[CH2:5][CH2:6][N:1]([CH2:7][CH2:8][C:9]([O:11][CH2:12][C:13]4[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=4)=[O:10])[CH2:2][CH2:3]3)=[O:40])[O:36][C:35]2=[O:42])=[CH:30][CH:29]=1)=[O:25])([CH3:22])([CH3:20])[CH3:21]

Participants

3

Reactant 2

HCID 19965556HCID 19965556, compoundHCID 54224547HCID 54224547, compound

Product 1

HCID 19965564Benzyl 3-{1-[3-(4-tert-butoxycarbonylaminomethylphenyl)-2-oxo-5-oxazolidinylcarbonyl]-4-piperazinyl}propionate

Procedure

In analogy to Example 4, reaction of benzyl 3-(1-piperazinyl)propionate and 3-(4-tert-butoxycarbonylaminomethylphenyl)-2-oxo-5-oxazolidinecarboxylic acid gives benzyl 3-{1-[3-(4-tert-butoxycarbonylaminomethylphenyl)-2-oxo-5-oxazolidinylcarbonyl]-4-piperazinyl}propionate, m.p. 128°-130°.

Sources & evidence

ORD record
ord-ee23afdfc77f4115abecdf4da23076cb
Source dataset
uspto-grants-1997_03
Patent number
US05614535

Reaction notes

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