Acetic Acid → HCID 131719942, compound

Participants

Reaction Steps

0.6 g of benzyl 2-{1-[3-(4-aminomethylphenyl)-2-oxo-5-oxazolidinylcarbonyl]-4-piperazinyl}acetate, dihydrochloride, is hydrogenated over Pd/charcoal, in a mixture of 30 ml of methanol, 5 ml of water and 5 ml of glacial acetic acid. The reaction mixture is filtered and the filtrate is concentrated in vacuo. Trituration of the crude product with ethyl acetate gives 2-{1-[3-(4-aminomethylphenyl)-2-oxo-5-oxazolidinylcarbonyl]-4-piperazinyl}acetic acid, dihydrochloride, m.p. 91° (decomposition).

Provenance & Evidence