Methanol → HCID 86750599, compound

Participants

Reaction Steps

A mixture of 5-[3-[4-[3-(5-methyl-2-phenyl-4-oxazolyl)propionyl]phenyl]propyl]-2,4-oxazolidinedione (0.28 g), hydroxylamine hydrochloride (0.09 g), sodium acetate (0.11 g) and 80% methanol (20 ml) was stirred under refluxing conditions for 2 hours. The reaction mixture was poured over water; the resulting crystal was collected by filtration to yield 5-[3-[4-[1-hydroxyimino-3-(5-methyl-2-phenyl-4-oxazolyl)propyl]phenyl]propyl]-2,4-oxazolidinedione (0.26 g, 90%), which was then recrystallized from dichloromethane-methanol to yield colorless prisms having a melting point of 185°-186° C.

Provenance & Evidence