HCID 54068121, compound → HCID 70107262, compound

Participants

Reaction Steps

A mixture of 5-[4-[3-(5-methyl-2-phenyl-4-oxazolyl)propionyl]benzylidene]-2,4-oxazolidinedione (0.75 g), palladium-carbon (5%, 0.75 g) and tetrahydrofuran (THF) (70 ml) was subjected to catalytic hydrogenation at 3 atm and room temperature. After the catalyst was filtered out, the filtrate was concentrated under reduced pressure. The residue was purified by silica gel column chromatography. From the fraction eluted with chloroform-ethyl acetate (1:1, v/v), 5-[4-[1-hydroxy-3-(5-methyl-2-phenyl-4-oxazolyl)propyl]benzyl]-2,4-oxazolidinedione (0.4 g, 53%) was obtained, which was then recrystallized from dichloromethane-methanol-isopropyl ether to yield colorless needles having a melting point of 154°-155° C.

Provenance & Evidence