1,4-Dioxane → HCID 19965610, compound

Participants

Reaction Steps

A mixture of methyl (E)-4-[2-(5-methyl-4-phenyl-2-thiazolyl)vinyl]benzoate (9.5 g), palladium-carbon (5%, 1.0 g) and dioxane (70 ml)-methanol (60 ml) was subjected to catalytic hydrogenation at 1 atm and room temperature. After the catalyst was filtered off, the filtrate was concentrated under reduced pressure to yield methyl 4-[2-(5-methyl-4-phenyl-2thiazolyl)ethyl]benzoate (9.0 g, 94%), which was then recrystallized from hexane to yield colorless plates having a melting point of 52°-53° C.

Provenance & Evidence