HCID 19965610, compound → HCID 53802020, compound

HRID 977252Notes

Reaction equation

HRID 977252 reaction equation
[CH3:1][C:2]1[S:6][C:5]([CH2:7][CH2:8][C:9]2[CH:18]=[CH:17][C:12]([C:13](OC)=[O:14])=[CH:11][CH:10]=2)=[N:4][C:3]=1[C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1.[H-].[Al+3].[Li+].[H-].[H-].[H-]>>[CH3:1][C:2]1[S:6][C:5]([CH2:7][CH2:8][C:9]2[CH:18]=[CH:17][C:12]([CH2:13][OH:14])=[CH:11][CH:10]=2)=[N:4][C:3]=1[C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1

Participants

3

Reactant 2

HCID 19965610HCID 19965610, compoundHCID 21226445Aluminium lithium hydride

Product 1

HCID 53802020HCID 53802020, compound

Procedure

Methyl 4-[2-(5-methyl-4-phenyl-2-thiazolyl)ethyl]benzoate was reduced with lithium aluminum hydride in the same manner as in Reference Example 12 to yield 4-[2-(5-methyl-4-phenyl-2-thiazolyl)ethyl]benzyl alcohol, which was then recrystallized from ethyl acetate-hexane to yield colorless prisms having a melting point of 62°-63° C.

Sources & evidence

ORD record
ord-dada8a92b38a43d780a84e25ddefe149
Source dataset
uspto-grants-1997_03
Patent number
US05614544

Reaction notes

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