HCID 19965653, compound → HCID 86750600, compound

Participants

Reaction Steps

A mixture of (E,E)-3-[4-[2-[5-methyl-2-(2-naphthyl)-4-oxazolyl]vinyl]phenyl]-2-propenol (2.80 g), activated manganese dioxide (8.40 g) and chloroform (150 ml) was stirred at room temperature for 16 hours. After the manganese dioxide was filtered off, the filtrate was concentrated under reduced pressure. The residue was subjected to silica gel chromatography to yield (E)-4-[2-[5-methyl-2-(2-naphthyl)-4-oxazolyl]vinyl]cinnamaldehyde (2.50 g, 90%) from the fraction eluted with chloroform, which was then recrystallized from dichloromethane-methanol to yield light yellow prisms having a melting point of 213°-214° C.

Provenance & Evidence