HCID 19965628, compound → HCID 53720755, compound

HRID 977260Notes

Reaction equation

HRID 977260 reaction equation
[CH3:1][C:2]1[S:6][C:5]([CH2:7][CH2:8][C:9]2[CH:14]=[CH:13][C:12](/[CH:15]=[CH:16]/[CH2:17][OH:18])=[CH:11][CH:10]=2)=[N:4][C:3]=1[C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1>[O-2].[O-2].[Mn+4]>[CH3:1][C:2]1[S:6][C:5]([CH2:7][CH2:8][C:9]2[CH:14]=[CH:13][C:12]([CH:15]=[CH:16][CH:17]=[O:18])=[CH:11][CH:10]=2)=[N:4][C:3]=1[C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1

Participants

3

Reactant 1

HCID 19965628HCID 19965628, compound

Product 1

HCID 53720755HCID 53720755, compound

Reagents, catalysts & solvents 1

HCID 178418406HCID 178418406, compoundCatalyst

Procedure

(E)-3-[4-[2-(5-Methyl-4-phenyl-2-thiazolyl)ethyl]phenyl]-2-propenol was oxidized with activated manganese dioxide in the same manner as in Reference Example 25 to yield 4-[2-(5-methyl-4-phenyl-2-thiazolyl)ethyl]cinnamaldehyde, which was then recrystallized from ethyl acetate-hexane to yield colorless prisms having a melting point of 94°-95° C.

Sources & evidence

ORD record
ord-f6364294c6cb47069de407f61b1fa415
Source dataset
uspto-grants-1997_03
Patent number
US05614544

Reaction notes

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