Acetic Anhydride → HCID 19965633, compound

Participants

Reaction Steps

After a mixture of 5-[4-[2-[2-(2-furyl)-5-methyl-4-oxazolyl]ethyl]phenyl]pentan-1-al (2.2 g), sodium cyanide (0.383 g), acetic anhydride (0.796 g), benzyltributylammonium chloride (0.608 g) and dichloromethane (40 ml)water (10 ml) was stirred at room temperature for 2 hours, the organic layer was separated, washed with water, dried (MgSO4), and then concentrated under reduced pressure, to yield 2-acetoxy-6-[4-[2-[2-(2-furyl)-5-methyl-4-oxazolyl]ethyl]phenyl]hexanenitrile as an oily substance.

Provenance & Evidence