HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methanol → HCID 131719685, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methanol | HCID 887 | — |
| Reactant | Oxalic Acid | HCID 971 | — |
| Reactant | 4-Phenylpiperidin-4-ol | HCID 96387 | — |
| Reactant | 4-(oxiran-2-ylmethoxy)-1H-indole | HCID 605015 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | HCID 131719685 | HCID 131719685 | — |
Reaction Steps
The title compound was prepared in similar fashion from S)-(+)-4-(oxiranylmethoxy)-1H-indole and 4-hydroxy-4-phenylpiperidine. The resulting free base was dissolved in ethyl acetate, and precipitated with one equivalent of oxalic acid in ethyl acetate in 69% overall yield. FDMS m/e=366 (M+ of free base). α[D]589 =-10.45 (c=0.61, methanol).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05614523 |
| Source dataset | uspto-grants-1997_03 |
| ORD ID | ord-486f3e33921e4483a950daed8ad136f9 |
| Source note | uspto-grants-1997_03 |