(2s)-Glycidyl indol-4-yl ether → HCID 57238471, compound

Participants

Reaction Steps

The title compound was prepared in a fashion similar to that described in Example 193 from 5-fluoro-3-(1,2,3,6-tetrahydropyridin-4-yl)-1H-indole (1.00 g, 4.63 mmol) and (S)-(+)-4-(oxiranylmethoxy)-1H-indole (0.90 g, 4.8 mmol). The resulting free base was isolated as a white foam. Yield 1.04 g (55%). mp 95°-100° C. FDMS m/e=405 (M+ of free base). α[D]589 =5.91 (c=1.01, dimethylsulfoxide).

Provenance & Evidence