Ethyl chloroformate → Boc-Leu-DTrp(COOEt)-DNle-OBzl

HRID 977518Notes

Reaction equation

Cl[C:2]([O:4][CH2:5][CH3:6])=[O:3].[NH:7]([C:49]([O:51][C:52]([CH3:55])([CH3:54])[CH3:53])=[O:50])[C@H:8]([C:13]([NH:15][C@@H:16]([C:31]([NH:33][C@@H:34]([C:39]([O:41][CH2:42][C:43]1[CH:48]=[CH:47][CH:46]=[CH:45][CH:44]=1)=[O:40])[CH2:35][CH2:36][CH2:37][CH3:38])=[O:32])[CH2:17][C:18]1[C:26]2[C:21](=[CH:22][CH:23]=[CH:24][CH:25]=2)[N:20](C(OC)=O)[CH:19]=1)=[O:14])[CH2:9][CH:10]([CH3:12])[CH3:11]>>[NH:7]([C:49]([O:51][C:52]([CH3:55])([CH3:53])[CH3:54])=[O:50])[C@H:8]([C:13]([NH:15][C@@H:16]([C:31]([NH:33][C@@H:34]([C:39]([O:41][CH2:42][C:43]1[CH:48]=[CH:47][CH:46]=[CH:45][CH:44]=1)=[O:40])[CH2:35][CH2:36][CH2:37][CH3:38])=[O:32])[CH2:17][C:18]1[C:26]2[C:21](=[CH:22][CH:23]=[CH:24][CH:25]=2)[N:20]([C:2]([O:4][CH2:5][CH3:6])=[O:3])[CH:19]=1)=[O:14])[CH2:9][CH:10]([CH3:12])[CH3:11]

Participants

Reactant 2

HCID 10928Ethyl chloroformate

HCID 15298069Boc-Leu-DTrp(COOMe)-DNle-OBzl

Product 1

HCID 131719298Boc-Leu-DTrp(COOEt)-DNle-OBzl

Procedure

The title compound was prepared using ethyl chloroformate instead of methyl chloroformate in the same manner described in Example 1-(1) and (2).

Sources & evidence

ORD record: ord-b91cdfc8ac8944da849c07af2a98681e
Source dataset: uspto-grants-1997_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05614498

Reaction notes

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