Sodium Hydroxide → HCID 15661739, compound

HRID 977577Notes

Reaction equation

HRID 977577 reaction equation
C[O:2][C:3](=[O:24])[CH2:4][O:5][C:6]1[CH:11]=[CH:10][CH:9]=[C:8](/[CH:12]=[CH:13]/[CH:14]([OH:23])[CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH3:22])[N:7]=1.[OH-].[Na+]>CO>[OH:23][CH:14]([CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH3:22])/[CH:13]=[CH:12]/[C:8]1[N:7]=[C:6]([O:5][CH2:4][C:3]([OH:24])=[O:2])[CH:11]=[CH:10][CH:9]=1

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 15661737HCID 15661737, compound

Product 1

HCID 15661739HCID 15661739, compoundYield 83.5%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

Under the conditions of example 2, 25 mg of 2-{6-[(1E)-(3RS)-3-hydroxy-1-undecenyl]-2-pyridyloxy}-acetic acid methyl ester in 1.5 ml of methanol is saponified with 1.5 ml of 1 n sodium hydroxide solution and worked up. 20 mg of the title compound is obtained as bright yellow oil.

Sources & evidence

ORD record
ord-0235eac86a5d4c50b067aa336a36eab7
Source dataset
uspto-grants-1997_03
Patent number
US05614634

Reaction notes

Loading…