Tetrahydrofuran → HCID 19966195, compound

HRID 977820Notes

Reaction equation

HRID 977820 reaction equation
[CH:1]1([CH2:7][Mg]Br)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.O1CCCC1.[C:15]([C:19]1[CH:24]=[CH:23][C:22]([CH2:25][CH2:26][CH:27]=[O:28])=[CH:21][C:20]=1[NH:29][C:30](=[O:46])[CH2:31][CH:32]1[C:45]2[CH:44]=[CH:43][CH:42]=[CH:41][C:40]=2[O:39][C:38]2[C:33]1=[CH:34][CH:35]=[CH:36][CH:37]=2)([CH3:18])([CH3:17])[CH3:16].[Cl-].[NH4+]>C(OCC)C>[C:15]([C:19]1[CH:24]=[CH:23][C:22]([CH2:25][CH2:26][CH:27]([OH:28])[CH2:7][CH:1]2[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]2)=[CH:21][C:20]=1[NH:29][C:30](=[O:46])[CH2:31][CH:32]1[C:45]2[CH:44]=[CH:43][CH:42]=[CH:41][C:40]=2[O:39][C:38]2[C:33]1=[CH:34][CH:35]=[CH:36][CH:37]=2)([CH3:18])([CH3:16])[CH3:17]

Participants

6

Reactant 4

HCID 8028Tetrahydrofuran2×HCID 25517Ammonium ChlorideHCID 19966225HCID 19966225, compoundHCID 178419664HCID 178419664, compound

Product 1

HCID 19966195HCID 19966195, compound

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent2×

Conditions

Temperature
-78 °C

Procedure

0.18 ml of a 1M solution of cyclohexylmethylmagnesium bromide in diethyl ether was added to 2 ml of tetrahydrofuran, and the mixture was cooled to -78° C. 2 ml of a tetrahydrofuran solution containing 50 mg (0.12 mmol) of N-[2-t-butyl-5-(3-oxopropyl)phenyl]-2-(9H-xanthen-9-yl)acetamide (prepared as described in Preparation 19) was then added dropwise to this solution, over a period of 5 minutes. The mixture was then stirred for 40 minutes at this temperature, after which the temperature was allowed to return gradually to 0° C. The reaction was then stopped by the addition of a saturated aqueous solution of ammonium chloride. Diethyl ether was added, which caused the title compound to be distributed between the organic solvent and water. The organic layer was separated and washed with water, after which the solvent was removed by distillation under reduced pressure. The resulting residue was subjected to column chromatography through 10 g of silica gel. Elution with a 100:15 by volume mixture of methylene chloride and ethyl acetate afforded 41 mg (yield 67%) of the title compound as crystals, melting at 145°-146° C. (after recrystallization from a mixture of methylene chloride and diethyl ether).

Workup

  1. additionwas then added dropwise to this solution, over a period of 5 minutes
  2. customto return gradually to 0° C

Sources & evidence

ORD record
ord-1438930326b141aa87ad250f7e6070a5
Source dataset
uspto-grants-1997_03
Patent number
US05614550

Reaction notes

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