N-(2-t-butyl-5-formylphenyl)-2-(9H-xanthen-9-yl)acetamide → N-[2-t-Butyl-5-(6-cyclohexyl-1-hydroxyhexyl)phenyl]-2-(9H-xanthen-9-yl)acetamide

HRID 977825Notes

Reaction equation

HRID 977825 reaction equation
[CH:1]1([CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][Mg]I)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[C:14]([C:18]1[CH:23]=[CH:22][C:21]([CH:24]=[O:25])=[CH:20][C:19]=1[NH:26][C:27](=[O:43])[CH2:28][CH:29]1[C:42]2[CH:41]=[CH:40][CH:39]=[CH:38][C:37]=2[O:36][C:35]2[C:30]1=[CH:31][CH:32]=[CH:33][CH:34]=2)([CH3:17])([CH3:16])[CH3:15]>>[C:14]([C:18]1[CH:23]=[CH:22][C:21]([CH:24]([OH:25])[CH2:11][CH2:10][CH2:9][CH2:8][CH2:7][CH:1]2[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]2)=[CH:20][C:19]=1[NH:26][C:27](=[O:43])[CH2:28][CH:29]1[C:30]2[CH:31]=[CH:32][CH:33]=[CH:34][C:35]=2[O:36][C:37]2[C:42]1=[CH:41][CH:40]=[CH:39][CH:38]=2)([CH3:17])([CH3:15])[CH3:16]

Participants

3

Reactant 2

HCID 19966116N-(2-t-butyl-5-formylphenyl)-2-(9H-xanthen-9-yl)acetamideHCID 178506592HCID 178506592, compound

Product 1

HCID 19965982N-[2-t-Butyl-5-(6-cyclohexyl-1-hydroxyhexyl)phenyl]-2-(9H-xanthen-9-yl)acetamide

Procedure

Following a procedure similar to that described in Example 14, but using 5-cyclohexylpentylmagnesium iodide and N-(2-t-butyl-5-formylphenyl)-2-(9H-xanthen-9-yl)acetamide (prepared as described in Preparation 15) as starting materials, in relative proportions similar to those used in that Example, the title compound was obtained as a foam-like substance.

Sources & evidence

ORD record
ord-9551f8b9d31e41ee862b92e9b24b1cba
Source dataset
uspto-grants-1997_03
Patent number
US05614550

Reaction notes

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