2,2-Dimethyldodecanoic acid → N-{2-t-Butyl-5-[4-cyclohexyl-3-(t-butyldimethylsilyloxy)butyl]phenyl}-2,2-dimethyldodecanamide

HRID 977890Notes

Reaction equation

HRID 977890 reaction equation
[CH3:1][C:2]([CH3:16])([CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH3:15])[C:3]([OH:5])=O.[C:17]([C:21]1[CH:27]=[CH:26][C:25]([CH2:28][CH2:29][CH:30]([O:38][Si:39]([C:42]([CH3:45])([CH3:44])[CH3:43])([CH3:41])[CH3:40])[CH2:31][CH:32]2[CH2:37][CH2:36][CH2:35][CH2:34][CH2:33]2)=[CH:24][C:22]=1[NH2:23])([CH3:20])([CH3:19])[CH3:18]>>[C:17]([C:21]1[CH:27]=[CH:26][C:25]([CH2:28][CH2:29][CH:30]([O:38][Si:39]([C:42]([CH3:45])([CH3:44])[CH3:43])([CH3:41])[CH3:40])[CH2:31][CH:32]2[CH2:33][CH2:34][CH2:35][CH2:36][CH2:37]2)=[CH:24][C:22]=1[NH:23][C:3](=[O:5])[C:2]([CH3:1])([CH3:16])[CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH3:15])([CH3:20])([CH3:18])[CH3:19]

Participants

3

Reactant 2

HCID 42657262,2-Dimethyldodecanoic acidHCID 199662172-t-Butyl-5-[4-cyclohexyl-3-(t-butyldimethylsilyloxy)butyl]aniline

Product 1

HCID 19966100N-{2-t-Butyl-5-[4-cyclohexyl-3-(t-butyldimethylsilyloxy)butyl]phenyl}-2,2-dimethyldodecanamide

Procedure

Following a procedure similar to that described in Example 21, but using 2,2-dimethyldodecanoic acid and 2-t-butyl-5-[4-cyclohexyl-3-(t-butyldimethylsilyloxy)butyl]aniline [prepared by a procedure similar to that described in Preparation 11(i)] as starting materials, in relative proportions similar to those used in that Example, the title compound was obtained as a foam-like material.

Workup

  1. customprepared by a procedure similar to

Sources & evidence

ORD record
ord-5664072b131b4b979723bb87811ca586
Source dataset
uspto-grants-1997_03
Patent number
US05614550

Reaction notes

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