Sodium Hydroxide → HCID 3063695, compound

HRID 977922Notes

Reaction equation

HRID 977922 reaction equation
C(O)(=O)/C=C/C(O)=O.[CH3:9][O:10][C:11]1[CH:37]=[C:36]([O:38][CH3:39])[CH:35]=[CH:34][C:12]=1[CH2:13][N:14]1[CH2:19][CH2:18][N:17]([CH:20]([C:28]2[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=2)[C:21]2[CH:26]=[CH:25][C:24]([F:27])=[CH:23][CH:22]=2)[CH2:16][CH2:15]1.[OH-].[Na+]>>[CH3:9][O:10][C:11]1[CH:37]=[C:36]([O:38][CH3:39])[CH:35]=[CH:34][C:12]=1[CH2:13][N:14]1[CH2:19][CH2:18][N:17]([CH:20]([C:28]2[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=2)[C:21]2[CH:22]=[CH:23][C:24]([F:27])=[CH:25][CH:26]=2)[CH2:16][CH2:15]1

Participants

3

Reactant 2

HCID 14798Sodium HydroxideHCID 6447833101477-46-7

Product 1

HCID 3063695HCID 3063695, compoundYield 70.7%

Procedure

The 1-(2,4-dimethoxybenzyl)-4-(4-fluorobenzhydryl)piperazine fumarate obtained in Example 1 (2.0 g; 3.7 millimoles) was added to 20 ml of a 20% aqueous solution of sodium hydroxide. The resulting oily product was extracted with 20 ml of ethyl acetate. The ethyl acetate layer was dried over anhydrous magnesium sulfate. The solvent was evaporated under reduced pressure to give 1.1 g of 1-(2,4-dimethoxybenzyl)-4-(4-fluorobenzhydryl)piperazine as an oil.

Workup

  1. extractionThe resulting oily product was extracted with 20 ml of ethyl acetate
  2. dry with materialThe ethyl acetate layer was dried over anhydrous magnesium sulfate
  3. customThe solvent was evaporated under reduced pressure

Sources & evidence

ORD record
ord-3ede5ac3dcb8441984c09f0e7dda297c
Source dataset
uspto-grants-1987_05
Patent number
US04663325

Reaction notes

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