Sodium Hydroxide → HCID 3063697, compound

HRID 977923Notes

Reaction equation

HRID 977923 reaction equation
O.O.Cl.Cl.[CH3:5][O:6][C:7]1[CH:34]=[C:33]([O:35][CH3:36])[CH:32]=[CH:31][C:8]=1[CH2:9][N:10]1[CH2:15][CH2:14][N:13]([CH:16]([C:24]2[CH:29]=[CH:28][C:27]([F:30])=[CH:26][CH:25]=2)[C:17]2[CH:22]=[CH:21][C:20]([F:23])=[CH:19][CH:18]=2)[CH2:12][CH2:11]1.[OH-].[Na+]>>[CH3:5][O:6][C:7]1[CH:34]=[C:33]([O:35][CH3:36])[CH:32]=[CH:31][C:8]=1[CH2:9][N:10]1[CH2:15][CH2:14][N:13]([CH:16]([C:17]2[CH:22]=[CH:21][C:20]([F:23])=[CH:19][CH:18]=2)[C:24]2[CH:29]=[CH:28][C:27]([F:30])=[CH:26][CH:25]=2)[CH2:12][CH2:11]1

Participants

3

Reactant 2

HCID 14798Sodium HydroxideHCID 20204603HCID 20204603, compound

Product 1

HCID 3063697HCID 3063697, compoundYield 42.5%

Procedure

The 1-(2,4-dimethoxybenzyl)-4-[bis(4-fluorophenyl)methyl]piperazine dihydrochloride dihydrate obtained in Example 2 (3.0 g; 5.9 millimoles) was added to 30 ml of a 20% aqueous solution of sodium hydroxide. The resulting oily product was extracted with 30 ml of ethyl acetate. The ethyl acetate layer was dried over anhydrous magnesium sulfate. The solvent was evaporated under reduced pressure to give 1.1 g of 1-(2,4-dimethoxybenzyl)-4-[bis(4-fluorophenyl)methyl]piperazine as an oil.

Workup

  1. extractionThe resulting oily product was extracted with 30 ml of ethyl acetate
  2. dry with materialThe ethyl acetate layer was dried over anhydrous magnesium sulfate
  3. customThe solvent was evaporated under reduced pressure

Sources & evidence

ORD record
ord-26dc95110ce24a998702a8fcae5e5711
Source dataset
uspto-grants-1987_05
Patent number
US04663325

Reaction notes

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