Sodium Hydroxide → HCID 3063699, compound

HRID 977924Notes

Reaction equation

HRID 977924 reaction equation
C(O)(=O)/C=C/C(O)=O.[CH3:9][O:10][C:11]1[C:37]([O:38][CH3:39])=[C:36]([O:40][CH3:41])[CH:35]=[CH:34][C:12]=1[CH2:13][N:14]1[CH2:19][CH2:18][N:17]([CH:20]([C:28]2[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=2)[C:21]2[CH:26]=[CH:25][C:24]([F:27])=[CH:23][CH:22]=2)[CH2:16][CH2:15]1.[OH-].[Na+]>>[CH3:9][O:10][C:11]1[C:37]([O:38][CH3:39])=[C:36]([O:40][CH3:41])[CH:35]=[CH:34][C:12]=1[CH2:13][N:14]1[CH2:15][CH2:16][N:17]([CH:20]([C:28]2[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=2)[C:21]2[CH:22]=[CH:23][C:24]([F:27])=[CH:25][CH:26]=2)[CH2:18][CH2:19]1

Participants

3

Reactant 2

HCID 14798Sodium HydroxideHCID 6447834101477-51-4

Product 1

HCID 3063699HCID 3063699, compoundYield 67%

Procedure

The 1-(2,3,4-trimethoxybenzyl)-4-(4-fluorobenzhydryl)piperazine fumarate obtained in Example 3 (3.0 g; 5.3 millimoles) was added to 30 ml of a 20% aqueous solution of sodium hydroxide. The resulting oily product was extracted with 30 ml of ethyl acetate. The ethyl acetate layer was dried over anhydrous magnesium sulfate. The solvent was evaporated under reduced pressure to give 1.6 g of 1-(2,3,4-trimethoxybenzyl)-4-(4-fluorobenzhydryl)-piperazine as an oil.

Workup

  1. extractionThe resulting oily product was extracted with 30 ml of ethyl acetate
  2. dry with materialThe ethyl acetate layer was dried over anhydrous magnesium sulfate
  3. customThe solvent was evaporated under reduced pressure

Sources & evidence

ORD record
ord-237f807875af4c64ba8a29a61ae30bba
Source dataset
uspto-grants-1987_05
Patent number
US04663325

Reaction notes

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